Description
Apoptosis is a selective process of genetically programmed cell death which occurs during normal cellular differentiation and development of multicellular organisms. This process is also involved in tissue homeostasis, pathological conditions and aging. Cells undergoing apoptosis are characterized by cell volume loss, plasma membrane blebbing, nuclear condensation, and endonucleolytic degradation of DNA at nucleosomal intervals. In vertebrates, T cell development in the thymus and development of the nervous system are probably the best characterized systems for the study of programmed cell death. Studies of the bcl-2 oncogene suggest additional pathways that may involve other proteins that could regulate Bcl-2 activity. Several new Bcl-2 related proteins, such as Apaf-1, Bax, Bruce, HILP/XIAP, Nip-1, p53, Bcl-2, Bcl-x and Bad, have been used as a screening panel in apoptosis.
Size
10 ug
Concentration
250 µg/ml
Application
Western blot Routinely Tested
Preparation and Storage
Store undiluted at -20°C.
Reviews
There are no reviews yet.