The Pan Melanoma staining combination increases sensitivity for melanomas. Since many skin biopsies are small, the triple stain conserves valuable tissue while saving time. Melan A (brown cytoplasmic) is a useful addition to melanoma panels as it is specific for melanocytic lesions. Tyrosinase (brown cytoplasmic) is a key enzyme involved in the initial stages of melanin biosynthesis. Tyrosinase is a more sensitive marker when compared to HMB45 and MART-1. It also labels a higher percentage of desmoplastic melanomas than HMB45. S100 stains Schwannomas, ependymomas, astrogliomas, almost all benign and malignant melanomas and their metastases. S100 (nuclear red) protein is also expressed in antigen presenting cells, such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes.
KIT COMPONENTS (100 reactions)
- 50x DAB Chromogen 1 x 0.5ml
- Biotinylated goat anti-rabbit IgG(H+L) 1 x 15ml
- DAB substrate 1 x 15ml
- Hydrogen Peroxide Block 1 x 15ml
- Protein block 1 x 15ml
- Streptavidin Peroxidase 1 x 15ml
- Rabbit anti-human Pan Melanoma
Store at +4°C. Please refer to protocols.
The products is “”FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES”””
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