Autoimmune pancreatitis typically produces an enlarged pancreas with narrowing of the pancreatic duct, and can mimic carcinoma. It was shown that the pancreatic tissue from patients with autoimmune pancreatitis often shows moderate or marked infiltration by IgG4-positive plasma. IgG4 staining in patients with chronic alcoholic pancreatitis and pancreatic ductal adenocarcinoma was rarely observed. IgG4-positive plasma cells are a useful marker for the tissue diagnosis of autoimmune pancreatitis. Elevated IgG4+ to IgG+ plasma cell ratio (IgG4/IgG ratio) is helpful in distinguishing IgG4-related from non IgG4-related inflammatory conditions.
KIT COMPONENTS (100 reactions)
- 50x DAB Chromogen 1 x 0.5ml
- Biotinylated goat anti-rabbit IgG(H+L) 1 x 15ml
- DAB substrate 1 x 15ml
- Hydrogen Peroxide Block 1 x 15ml
- Protein block 1 x 15ml
- Streptavidin Peroxidase 1 x 15ml
- Rabbit anti-human IgG4
Store at +4°C. Please refer to protocols.
The products is “”FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES”””
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