Inactive cREL resides in the cytoplasm and translocates to the nucleus upon activation. Strong, homogeneous nuclear cREL staining has been observed in primary mediastinal large B-cell lymphoma whereas nuclear cREL expression is more variable in other forms of diffuse large B-cell lymphoma (DLBCL). Evaluation of cREL nuclear expression combined with germinal center B-cell (GCB) and non- GCB phenotyping by IHC may improve patient risk stratification in DLBCL.
KIT COMPONENTS (100 reactions)
- 50x DAB Chromogen 1 x 0.5ml
- Biotinylated goat anti-rabbit IgG(H+L) 1 x 15ml
- DAB substrate 1 x 15ml
- Hydrogen Peroxide Block 1 x 15ml
- Protein block 1 x 15ml
- Streptavidin Peroxidase 1 x 15ml
- Rabbit anti-human cREL
Store at +4°C. Please refer to protocols.
The products is “”FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES”””