Beta-catenin is an important regulator of cell–cell adhesion and embryogenesis. Mutations of etacatenin could lead to some human cancers. Normal cells show membrane staining for beta-catenin, while cytoplasmic and/or nuclear staining is abnormal. Dysregulation of beta-catenin occurs in Gardner syndrome, where it leads to both familial adenomatous polyposis and fibromatosis. Nuclear location of beta-catenin also occurs in colon and endometrioid ovarian carcinomas as well as in synovial sarcoma, osteosarcoma, liposarcoma, palisaded myofibroblastoma, and other sarcomas.
KIT COMPONENTS (100 reactions)
- 50x DAB Chromogen 1 x 0.5ml
- Biotinylated goat anti-rabbit IgG(H+L) 1 x 15ml
- DAB substrate 1 x 15ml
- Hydrogen Peroxide Block 1 x 15ml
- Protein block 1 x 15ml
- Streptavidin Peroxidase 1 x 15ml
- Rabbit anti-human Beta Catenin
Store at +4°C. Please refer to protocols.
The products is “”FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES”””